In this episode of The Evolution of Medicine, host James Maskell interviews registered dietitian Ashley Koff about her new book Your Best Shot. The conversation explores the seismic impact of GLP-1 agonists like Ozempic and Wegovy—and how functional medicine can pivot from a “weight loss” mindset to a “weight health” approach.

Koff reframes these medications not as magic bullets, but as biosimilar hormone replacement tools that “switch on” receptor sites—without repairing the underlying ecosystem. She outlines a five-part Weight Health Hormone assessment and introduces a Physician–Dietitian–Health Coach triad to ensure sustainable outcomes.

The episode challenges practitioners to stay “agnostic about the agonist” and instead focus on metabolic repair, patient education, and structured team-based care.

About the Guest:
Ashley Koff, RD is a registered dietitian and functional nutrition expert focused on metabolic health, personalized nutrition, and hormone signaling. She is the author of Your Best Shot and advocates for a “Weight Health” approach that integrates assessment, repair, and team-based implementation.

Ashley Koff, RD
Website: https://thebetternutritionprogram.com/your-best-shot/#Order?utm_source=ig&utm_medium=social&utm_content=link_in_bio&fbclid=PAZXh0bgNhZW0CMTEAc3J0YwZhcHBfaWQMMjU2MjgxMDQwNTU4AAGn0Q9_BL_AVS4TE9ropSLtTkwP2y5sIOqKsbxZaaKPv3nNMm0Tq8QuWidcGUk_aem_U9Z5knW9eqsiMjw19fzflA 

Instagram: https://www.instagram.com/ashleykoffapproved/?hl=en
Facebook: https://www.facebook.com/ashleykoffapproved/
Linkedin: https://www.linkedin.com/in/ashley-koff/

James Maskell
Website: https://www.jamesmaskell.com/
Instagram: https://www.instagram.com/mrjamesmaskell 
Facebook: https://www.facebook.com/jamesedwardmaskell/ 
LinkedIn: https://www.linkedin.com/in/jamesmaskell


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In this episode of The Evolution of Medicine, host James Maskell outlines a pivotal shift for functional medicine practitioners. He argues that the era of the “artisan” solo practitioner is ending—and that survival in 2026 and beyond requires building scalable clinical infrastructure.

Maskell explains how AI-powered platforms, venture-backed telehealth companies, and direct-to-consumer lab brands are redefining patient expectations around speed, convenience, and affordability. To compete, functional medicine clinics must evolve into “full stack” models—combining objective data, team-based care, defined outcomes, and recurring membership structures.

This episode also launches a new initiative designed to help clinics operationalize that shift.

James Maskell is a healthcare entrepreneur and founder of The Evolution of Medicine. For over 20 years, he has worked to scale functional medicine through community-driven models, group visits, and practitioner infrastructure. His work focuses on moving medicine upstream—toward prevention, lifestyle intervention, and systems-based care.

Website: https://www.jamesmaskell.com/
Instagram: https://www.instagram.com/mrjamesmaskell 
Facebook: https://www.facebook.com/jamesedwardmaskell/ 
LinkedIn: https://www.linkedin.com/in/jamesmaskell


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This podcast is produced by DrTalks.com ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠
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In this episode of The Evolution of Medicine podcast, host James Maskell speaks with health educator and researcher Ari Whitten about why modern medicine has failed to meaningfully prevent or reverse Alzheimer’s disease—and how an evolutionary and lifestyle-based framework offers a far more effective path forward.

The conversation reframes Alzheimer’s not as an inevitable consequence of aging, but as a disease of evolutionary mismatch—the result of modern lifestyles that conflict with our ancient biological design. Drawing on anthropological data, long-term population studies, and emerging research on physiological resilience, Whitten explains why building “reserve capacity” may be the most powerful strategy for long-term brain health.

Ari Whitten is a health educator, researcher, and expert in energy metabolism and human performance. His work focuses on evolutionary health, mitochondrial function, and physiological resilience as foundations for preventing chronic disease. Ari is widely known for translating complex research into actionable lifestyle strategies that help people build robust health in the modern world.

Instagram: https://www.instagram.com/theenergyblueprint/?hl=en
Shop Supplements: https://theenergyblueprint.com/bf-sale-2025/
Spotify: https://open.spotify.com/show/38flatRKyeocmKUmEkVqrR
Apple Podcast: https://podcasts.apple.com/us/podcast/the-energy-blueprint-podcast/id1226660198

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This podcast is produced by DrTalks.com ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠
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In this episode of The Evolution of Medicine podcast, host James Maskell speaks with Dr. Matthew Bernstein about the emerging field of metabolic psychiatry. They explore how addressing metabolic health—particularly through ketogenic diets—can treat and, in some cases, reverse serious mental health conditions that conventional psychiatric medications often fail to resolve.

Through personal stories, clinical insights, and a forward-looking discussion on research and policy, the episode challenges the long-standing “chemical imbalance” narrative and reframes mental illness as a systemic, energy-based disorder rooted in metabolic dysfunction.

James Maskell interviews Dr. Matthew Bernstein on metabolic psychiatry, ketogenic diets, and the future of mental health care, exploring how metabolic health can reverse depression, bipolar disorder, and psychosis on The Evolution of Medicine Podcast.

Dr. Matthew Bernstein is a psychiatrist and pioneer in metabolic psychiatry. After a family health crisis involving his sons’ diagnosis of PANS (Pediatric Acute Neuropsychiatric Syndrome), he shifted away from medication-centric psychiatry toward addressing root causes such as metabolic dysfunction, inflammation, and immune dysregulation. He is the founder of Accord, an immersive metabolic health program near Boston.

Website: https://www.jamesmaskell.com/ 

X: https://x.com/mrjamesmaskell 

Instagram: https://www.instagram.com/mrjamesmaskell 

Facebook: https://www.facebook.com/jamesedwardmaskell/ 

Linkedin: https://www.linkedin.com/in/jamesmaskell

Thank you for listening.

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This podcast is produced by DrTalks.com ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

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